Table 1.
Characteristics of Study Sample by Baseline cTnT Concentration (N = 4221)a
| Characteristics | cTnT Concentration, pg/mL
|
P for Trend | ||||
|---|---|---|---|---|---|---|
| <3.00 (n = 1427) | 3.00–5.44 (n = 697) | 5.45–8.16 (n = 700) | 8.17–12.94 (n = 697) | >12.94 (n = 700) | ||
| Age, mean (SD), y | 70.4 (4.0) | 71.9 (4.7) | 72.9 (5.0) | 74.4 (5.7) | 76.3 (6.7) | <.001 |
|
| ||||||
| Men | 324 (22.7) | 234 (33.6) | 323 (46.1) | 362 (51.9) | 466 (66.6) | <.001 |
|
| ||||||
| Black | 250 (17.5) | 99 (14.2) | 97 (13.9) | 97 (13.9) | 139 (19.9) | .80 |
|
| ||||||
| Diabetes | 161 (11.3) | 98 (14.1) | 129 (18.4) | 146 (21.0) | 210 (30.0) | <.001 |
|
| ||||||
| Coronary heart disease | 167 (11.7) | 105 (15.1) | 134 (19.1) | 141 (20.2) | 193 (27.7) | <.001 |
|
| ||||||
| Hypertension | 700 (53.3) | 337 (54.8) | 363 (59.5) | 398 (67.8) | 364 (67.6) | <.001 |
|
| ||||||
| BP, mean (SD), mm Hg | ||||||
| Systolic | 132.6 (19.6) | 134.3 (19.8) | 138.0 (22.1) | 141.5 (21.8) | 142.8 (23.7) | <.001 |
|
| ||||||
| Diastolic | 70.4 (10.7) | 70.2 (10.4) | 70.7 (11.6) | 72.1 (11.5) | 72.0 (12.4) | <.001 |
|
| ||||||
| Estimated GFR <60 mL/min/1.73 m2 | 137 (13.1) | 101 (14.5) | 147 (21.0) | 179 (25.7) | 284 (40.6) | <.001 |
|
| ||||||
| Major ECG abnormality | 235 (17.0) | 156 (23.1) | 207 (30.3) | 237 (35.1) | 336 (50.5) | <.001 |
|
| ||||||
| Current or former smoker | 546 (38.3) | 286 (41.2) | 305 (43.6) | 299 (43.0) | 311 (44.4) | .003 |
|
| ||||||
| BMI, mean (SD) | 26.7 (4.7) | 26.5 (4.8) | 27.0 (5.0) | 27.0 (4.6) | 26.8 (4.6) | .97 |
|
| ||||||
| NT-proBNP, median (IQR), pg/mL | 79.5 (43.7–142.6) | 94.1 (50.6–178.3) | 116.5 (58.5–223.1) | 138.5 (75.9–301.6) | 228.7 (108.3–588.2) | <.001 |
|
| ||||||
| CRP, median (IQR) | 2.5 (1.3–4.3) | 2.3 (1.1–4.3) | 2.3 (1.3–4.2) | 2.5 (1.3–4.2) | 3.1 (1.6–6.7) | <.001 |
|
| ||||||
| LV mass by ECG, median (IQR), g | ||||||
| Men | 169.7 (156.9–184.2) | 171.4 (155.4–187.0) | 171.7 (155.8–188.2) | 171.0 (154.3–188.5) | 177.6 (159.0–202.0) | <.001 |
|
| ||||||
| Women | 133.5 (121.5–146.8) | 134.0 (121.2–148.2) | 136.5 (122.9–155.4) | 139.8 (124.4–157.2) | 136.8 (123.4–159.3) | <.001 |
|
| ||||||
| Left atrial diameter by echocardiogram, mean (SD), cm | 3.73 (0.59) | 3.84 (0.64) | 3.93 (0.65) | 3.96 (0.68) | 4.11 (0.72) | <.001 |
|
| ||||||
| Abnormal LVEF | 55 (4.1) | 35 (5.2) | 39 (5.8) | 69 (10.6) | 100 (15.8) | <.001 |
|
| ||||||
| LV mass index by echocardiogram, mean (SD), g/m2b | ||||||
| Women | 77.3 (19.5) | 79.4 (21.4) | 83.3 (23.5) | 86.5 (26.8) | 89.1 (23.7) | <.001 |
|
| ||||||
| Men | 85.9 (22.6) | 87.8 (23.3) | 90.9 (26.0) | 89.8 (24.1) | 96.9 (29.0) | <.001 |
Abbreviations: BMI, body mass index, calculated as weight in kilograms divided by height in meters squared; BP, blood pressure; CRP, C-reactive protein; cTnT, cardiac troponin T; ECG, electrocardiogram; GFR, glomerular filtration rate; IQR, interquartile range; LV, left ventricle; LVEF, left ventricular ejection fraction; NT-proBNP, N-terminal pro-type B natriuretic peptide.
a
Data are presented as No. (%) unless otherwise indicated. A cTnT concentration of less than 3.00 pg/mL is undetectable.
b
A total of 2739 participants were assessed.