Table 1.
Baseline Characteristics of Women (N=10 101) Randomized in RUTH
| Characteristic | Overall (N=10 101), No. (%) |
|---|---|
| Age | |
| ≤65 years | 3699 (36.6) |
| >65 and <70 years | 2471 (24.5) |
| ≥70 years | 3931 (38.9) |
| White | 8481 (84.0) |
| Region of the world | |
| Western Europe | 4679 (46.3) |
| Eastern Europe | 2310 (22.9) |
| Latin/South America | 1370 (13.6) |
| North America | 1029 (10.2) |
| Asia Pacific | 498 (4.9) |
| Africa | 215(2.1) |
| Body mass index | |
| ≤25 kg/m2 | 2416 (23.9) |
| >25 and ≤30 kg/m2 | 4052 (40.1) |
| >30 kg/m2 | 3603 (35.7) |
| *Current smoker | 1256 (12.4) |
| †Cardiovascular risk score category | |
| ≤5 | 3671 (36.3) |
| >5 and ≤9 | 3469 (34.3) |
| >9 | 2961 (29.3) |
| History of coronary heart disease | 5034 (49.8) |
| Prior estrogen therapy | 1399 (13.9) |
| Prior estrogen progestin therapy | 605 (6.0) |
| ‡Diabetes mellitus | 4607 (45.6) |
| Lower extremity arterial disease | 1083 (10.7) |
| Prior stroke | 860 (8.5) |
| History of atrial fibrillation | 482 (4.8) |
| §Hypertension | 7863 (77.8) |
| ∥Hyperlipidemia | 7381 (73.1) |
| Baseline medication use | |
| Statin | 4743 (47.0) |
| Beta blockers | 4794 (47.5) |
| Calcium channel blockers | 3579 (35.4) |
| Angiotensin-converting enzyme inhibitor or angiotensin receptor blocker | 4893 (48.4) |
| Diuretic | 3992 (39.5) |
| Warfarin | 417(4.1) |
| Aspirin | 5711 (56.5) |
| Nonaspirin antiplatelet | 298 (3.0) |
| Family history of deep vein clot | 650 (6.4) |
| Prior visible swelling in legs >24 hours | 452 (4.5) |
| Systolic blood pressure, mm Hg | 146 (20) |
| Diastolic blood pressure, mm Hg | 82 (10) |
| ¶Low-density lipoprotein cholesterol, mg/dL | 121.9 (37) |
| #triglyceride level, mg/dL | 158.7 (110) |
Smoking, self-reported smoking of an average of ≥10 cigarettes/day over the 6 months before Visit 1.
Cardiovascular risk score category, cardiovascular risk score calculated based on the presence of risk factors for a major coronary event.6
Diabetes, self-reported diabetes mellitus and use of oral hypoglycemic medication or insulin or fasting serum glucose >140 mg/dL at Visit 1.
Hypertension, self-reported hypertension and use of antihypertensives or systolic blood pressure >160 mm Hg or diastolic blood pressure >95 mm Hg on at least 2 measurements.
Hyperlipidemia, use of lipid-lowering medications or a fasting low-density lipoprotein cholesterol> 160 mg/dL or fasting high-density lipoprotein cholesterol <45 mg/dL with fasting triglycerides >250 mg/dL.
To convert values for low-density lipoprotein cholesterol to mmol/L, multiply by 0.0259.
To convert values for triglyceride level to mmol/L, multiply by 0.0112.