Table 2. Predictors for being in cluster and in major cluster for 787 patients with multidrug-resistant TB, Argentina, 2003–2009*.
| Characteristic | No. patients | % Patients in cluster | Unadjusted OR (95% CI) | Adjusted OR (95% CI)† | % Patients in major cluster‡ | Unadjusted OR (95% CI) | Adjusted OR (95% CI)§ |
|---|---|---|---|---|---|---|---|
| Age, y, n = 640 | |||||||
| <15 | 24 | 83.3 | 2.9 (0.9–8.9) | ND | 58.3 | 1.5 (0.6–3.6) | ND |
| 16–45 | 495 | 78.6 | 2.1 (1.4–3.2) | 2.5 (1.3–5.0) | 57.9 | 1.5 (1.0–2.2) | 1.0 (0.5–2.0) |
| >45 | 121 | 63.6 | 1 | 1 | 48.3 | 1 | 1 |
| Country of birth, n = 541 | |||||||
| Argentina | 412 | 80.1 | 2.7 (1.7–3.9) | 3.5 (1.9–6.4) | 66.7 | 7.6 (4.7–12.1) | 8.0 (4.3–15.0) |
| Other | 129 | 61.2 | 1 | 1 | 20.9 | 1 | 1 |
| Place of diagnosis, n = 787 | |||||||
| Hotspot¶ | 634 | 77.9 | 2.1 (1.5–3.1) | 1.6 (0.7–3.7) | 62.3 | 4.2 (2.9–6.2) | 5.9 (2.5–13.8) |
| Other | 153 | 62.1 | 1 | 1 | 28.1 | 1 | 1 |
| HIV status, n = 604 | |||||||
| Positive | 254 | 86.6 | 2.7 (1.7–4.1) | 2.4 (1.0–5.6) | 76.4 | 3.3 (2.-4.7) | 3.7 (1.8–7.7) |
| Negative | 350 | 70.9 | 1 | 1 | 49.4 | 1 | 1 |
| Previous TB, n = 557 | |||||||
| Yes | 313 | 71.9 | 0.7 (0.5–1.0) | 0.8 (0.5–1.5) | 51.8 | 0.7 (0.5–1.0) | 0.7 (0.4–1.2) |
| No | 244 | 79.1 | 1 | 1 | 59.4 | 1 | 1 |
| Site of disease, n = 775 | |||||||
| Pulmonary only | 698 | 74.1 | 0.6 (0.3–1.2) | 1.4 (0.5–4.2) | 55.0 | 0.8 (0.5–1.3) | 2.7 (1.1–7.0) |
| Other | 77 | 81.8 | 1 | 1 | 59.7 | 1 | 1 |
*Boldface indicates significance. TB, tuberculosis; OR, odds ratio; ND, not done. †Cluster model overall model fit p < 0.0001, Hosmer & Lemeshow test p = 0.5888, area under the receiver operating characteristic curve 0.723. ‡Cluster including >15 patients in the study period. §Major cluster model overall model fit p < 0.0001, Hosmer & Lemeshow test p = 0.7766, area under the receiver operating characteristic curve 0.793. ¶Area where a multidrug-resistant outbreak was previously documented.