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Comparison between human chondrocyte micromasses cultured in the optimized formulation and in the standard formulation, depicted as mean±standard deviation. There were significant increases in the gene expressions of (A) the ACAN:VCAN ratio, (B) SOX9, and (C) COMP (**p<0.01). There were no differences in gene expression for (D) the COLII:COLI ratio or (E) COLX.
