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. 2012 Jan;1(1):50–53. doi: 10.1089/biores.2012.0206

FIG. 2.

FIG. 2.

The effect of the cellular substrata on BMOL bipotential gene expression. Quantitative polymerase chain reaction of biliary and hepatic marker expression in BMOL cultured on plastic, laminin, and PU134. (A) Expression of the biliary markers, hepatocyte nuclear factors HNF1β and HNF6, on cells maintained on different matrices. Both HNF1β and HNF6 exhibited upregulation on laminin and PU134. (B) Expression of hepatic marker factors, HNF4α and HNF1α, on cells maintained on different matrices. HNF1α expression showed a significant upregulation on laminin and PU134. Nonsignificant (ns) change was observed for HNF4α. Relative expression refers to folds of induction of the gene compared with the endogenous gene control, PPIA. Data are expressed as mean±s.d., *p<0.05, **p<0.01, ***p<0.001, and n=3.