Table 2. BCL11B expression induces FOS expression in the OMT cells.
Gene Symbol | Gene Title | Fold change |
(mean±S.D) | ||
FOS | FBJ murine osteosarcoma viral oncogene homolog | 8.3±5.3 |
FOSB | FBJ murine osteosarcoma viral oncogene homolog B | 1.5±0.4 |
FRA1 | FOS-like antigen 1 | 1.3±0.4 |
FRA2 | FOS-like antigen 2 | 1.2±0.3 |
JUN | jun proto-oncogene | 2.0±0.3 |
JUNB | jun B proto-oncogene | 1.0±0.3 |
JUND | jun D proto-oncogene | 1.0±0.4 |
BCL6 | B-cell CLL/lymphoma 6 | 1.7±0.1 |
GATA3 | GATA binding protein 3 | 1.0±0.2 |
TCF8 | zinc finger E-box binding homeobox 1 | 2.0±0.4 |
IKAROS | IKAROS family zinc finger 1 | 1.2±0.2 |
HELIOS | IKAROS family zinc finger 2 | 1.6±0.4 |
FOXP3 | forkhead box P3 | 0.7±0.2 |
PCNA | proliferating cell nuclear antigen | 1.1±0.4 |
CCND1 | cyclin D2 | 0.9±0.3 |
CCND3 | cyclin D3 | 1.2±0.2 |
CCNE1 | cyclin E1 | 0.9±0.3 |
CCNA2 | cyclin A2 | 0.9±0.2 |
CDK2 | cyclin-dependent kinase 2 | 1.0±0.4 |
CDK4 | cyclin-dependent kinase 4 | 1.0±0.4 |
E2F1 | E2F transcription factor 1 | 1.0±0.5 |
E2F2 | E2F transcription factor 2 | 0.9±0.5 |
CDKN1A | cyclin-dependent kinase inhibitor 1A (p21, Cip1) | 1.1±0.2 |
CDKN1B | cyclin-dependent kinase inhibitor 1B (p27, Kip1) | 1.0±0.2 |
CDKN1C | cyclin-dependent kinase inhibitor 1C (p57, Kip2) | ND |
TP53 | tumor protein p53 | 1.3±0.4 |
IL2 | interleukin 2 | 2.6±1.6 |
CCR4 | chemokine (C-C motif) receptor 4 | 0.9±0.3 |
IL10 | interleukin 10 | ND |
ICAM PTP1C | intercellular adhesion molecule 1protein tyrosine phosphatase, non-receptor type 6 | 0.9±0.20.8±0.2 |
MYB | v-myb myeloblastosis viral oncogene homolog (avian) | 1.1±0.5 |
Tax | HTLV-1 regulatory and accessory genes | 1.2±0.4 |
HBZ | HTLV-1 bZIP factor gene | 1.0±0.3 |
The OMT cells were transfected with plasmids encoding GFP (control) or BCL11B-GFP. The cells with GFP fluorescence were isolated by FACS at 48 h after the transfection, and total RNA was extracted. The mRNA levels were quantified by RT-PCR, normalized to GAPDH and expressed relative to the GFP-expressing control cells.