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. 2013 Jan 30;8(1):e55004. doi: 10.1371/journal.pone.0055004

Figure 6. Electron micrographs of the stratum radiatum of the hippocampus and of the cerebellar molecular layer illustrating typical neuropathological hallmarks of prion disease.

Figure 6

(A): A typical spongiform vacuole (arrow) within the pyramidal cell layer of CA1 region at ES p.i. (B): Numerous vacuoles containing whorled membrane fragments (arrows) within the stratum radiatum at LS p.i. (C): A large spongiform vacuole containing secondary vacuoles within the stratum radiatum at LS p.i. with ongoing synaptic pathology adjacent. (D): Proximal part of the molecular layer in the cerebellum at ES p.i. containing spongiform vacuole (arrow) with normal appearing synaptic structures in the vicinity. (E): Swollen neuronal terminal in the molecular layer of the cerebellum containing vacuole-like structure with numerous whorled membrane fragments in a 22L-animal at LS p.i. (F): Bergmann glia with bundles of fibrils (arrow) in the molecular layer of the cerebellum from a 22L-animal at ES p.i. (G, H): Numerous glial cells (arrows) within the stratum radiatum of the hippocampus with ongoing synaptic pathology at LS p.i. (I): A detail of a double-membrane enclosed autophagic vacuoles within the stratum radiatum of the hippocampus at LS p.i. (J): An autophagic vacuole (arrow) in the molecular layer of the cerebellum at LS p.i. in a 22L-animal. Scale bars: 10 µm (A, B); 5 µm (C, G); 1 µm (D, E, H, I); 2 µm (F, J).