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. 2013 Jan 30;8(1):e55646. doi: 10.1371/journal.pone.0055646

Figure 7. Hypothetical pathways that contribute to the GSH release from swollen thymocytes.

Figure 7

The scheme depicts three main pathways of the osmotic swelling-induced GSH release revealed in the present study: VSOR anion channel (sensitive to DCPIB and phloretin), SLC22A/OAT-like transporter (sensitive to PAH), and SLCO/OATP-like transporter (stimulated by the substrates such as probenecid, taurocholate and estrone sulfate). Significant contribution of the MRP protein (sensitive to MK571 and probenecid) was not detected in the present study. The grey box denotes other possible routes for GSH exit from swollen thymocytes.