FIG. 5.

Coordination of gene expression and metabolic fluxes in glycolysis (A), the TCA cycle (B), and lysine biosynthesis (C) during batch cultivation of lysine-producing C. glutamicum ATCC 13287. For substrate uptake, glucose uptake flux (Fig. 2) and the expression of PTS components (Table 4) were considered. In the other cases (B to D), the intracellular flux data obtained after 5.8, 6.9, and 8.1 h (Fig. 4) were related to expression levels at 5.6, 6.8, and 7.7 h (Table 5), respectively.