Table 1. Presentation of TRPM4 variants.

mRNA	Protein	Grantham [0-215]	Splicing	Interspecies conservation	InterTRPM conservation	Protein domain	Controls	European American	African American	Total 1	Fisher exact test	Total 2	Fisher exact test
c. 430C>T	p.R144W	101	–	mammals	0/7	N-term. Intracyto	0/2040	0/3490	0/1854	0/5530	0.0429*	0/7384	0.0325*
c. 1294G>A	p.A432T	58	–	vertebrates	7/7	N-term. Intracyto	0/300	0/3501	0/1864	0/3801	0.0612	0/5665	0.0419*
c. 1663G>A	p.G555R	125	–	mammals except rodent	0/7	N-term. Intracyto	0/2000	0/5366	0/3501	0/7366	0.0323*	0/10867	0.0245*
c. 1744G>A	p.G582S	56	crypticdonorsite	mammals	4/7	N-term. Intracyto	0/2000	0/5356	0/3495	0/7356	0.0326*	0/10851	0.0223*
c.2317T>A	p.F773I	21	–	primates	0/7	1st extra-cellular loop	0/2000	0/5219	0/3405	0/7219	0.0332*	0/10624	0.0228*
c.2336C>G	p.P779R	103	–	invertebrates	6/7	Transmembrane S2	0/2000	0/5219	0/3405	0/7219	0.0332*	0/10624	0.0228*
c. 2618C>T	p.T873I	89	–	several mammals	0/7	Transmembrane S3	0/2000	0/6974	0/3626	0/8974	0.0269*	0/12600	0.0193*
c.2209G>A	p.G737R	125	–	several mammals	0/7	1st extra-cellular loop	1/2000	7/7007	6/3732	8/9007	0.0279*	14/12739	0.0365*
c.2531G>A	p.G844D	94	–	mammals	0/7	1st intra-cellular loop	4/2000	12/6780	0/3626	16/8780	0.0143*	16/12406	0.0056*
c.2561A>G	p.Q854R	43	–	primates + fish	3/7	1st intra-cellular loop	2/2000	8/6966	1/3713	10/8966	0.0045*	11/12679	0.0022*
c.2740A>T	p.K914X	–	–	mammals + fish	4/7	End of S4	2/1914	12/7008	3/3735	14/8922	0.0100*	17/12657	0.0063*
c.3224T>C	p.L1075P	98	–	invertebrates	4/7	TRP domain	0/2052	1/7019	0/3738	1/9071	0.0525	1/12809	0.0376*
c.1458_1493del36	p.K487_L498del	–	–	primates	0/7	N-term. Intracyto	4/576				0.8322
c.3611C>T	p.P1204L	98		vertebrates	0/7	C-term. Intracyto	6/1100	25/6957	0/3708	31/8057	0.6473	31/11765	0.4875

(*: Fisher exact test positive) TRPM4 RefSeq NM_017636.3, OMIM 606936.