Table 3. Association of IL-13 with asthma phenotypes, by additive genetic model.
SNP | Asthma | Wheeze | Early-onset asthma† | Late-onset asthma‡ | ||||||||||||
OR | 95% CI | P value | FDR | OR | 95% CI | P value | FDR | OR | 95% CI | P value | FDR | OR | 95% CI | P value | FDR | |
rs1800925 | 1.2 | (0.9,1.5) | 0.21 | 0.41 | 1.3 | (1.1,1.5) | 0.01 | 0.03 | 1.2 | (0.9,1.5) | 0.23 | 0.60 | 1.2 | (0.8,1.7) | 0.41 | 0.76 |
rs2066960 | 0.9 | (0.7,1.1) | 0.12 | 0.41 | 0.9 | (0.7,1.0) | 0.02 | 0.04 | 1.0 | (0.8,1.2) | 0.60 | 0.60 | 0.7 | (0.5,1.0) | 0.03 | 0.13 |
rs20541 | 1.1 | (0.9,1.3) | 0.45 | 0.49 | 1.2 | (1.0,1.4) | 0.04 | 0.04 | 1.1 | (0.9,1.4) | 0.44 | 0.60 | 1.1 | (0.8,1.5) | 0.66 | 0.76 |
rs848 | 1.1 | (0.9,1.3) | 0.49 | 0.49 | 1.2 | (1.0,1.4) | 0.04 | 0.04 | 1.1 | (0.9,1.3) | 0.54 | 0.60 | 1.0 | (0.8,1.4) | 0.76 | 0.76 |
Models are adjusted for age, sex, parental history of asthma, parental history of atopy, in utero exposures to maternal smoking, ETS, dampness, incense burning, pet ownership at home and community.
Early-onset: asthma diagnosed ≦5 yr of age.
Late-onset: asthma diagnosed >5 yr of age.