Table 5. Association of IL-13 haplotypes with asthma phenotypes among children.
| Asthma | Wheeze | Early-onset asthma† | Late-onset asthma‡ | |||||
| OR | 95%CI | OR | 95%CI | OR | 95%CI | OR | 95%CI | |
| h0100a | 1 | 1 | 1 | 1 | ||||
| h0000a | 1.1 | (0.9,1.4) | 1.1 | (0.9,1.4) | 1.0 | (0.7,1.3) | 1.5 | (1.0,2.2) |
| h0011a | 1.2 | (0.9,1.6) | 1.2 | (0.9,1.5) | 1.2 | (0.8,1.6) | 1.3 | (0.8,2.1) |
| h1011a | 1.2 | (0.9,1.7) | 1.5 | (1.2,1.8) | 1.2 | (0.8,1.7) | 1.5 | (0.9,2.4) |
| Others | 0.8 | (0.6,1.2) | 1.0 | (0.8,1.4) | 0.7 | (0.5,1.2) | 1.0 | (0.5,1.9) |
| globe p value | 0.22 | 0.03 | 0.34 | 0.21 | ||||
Models are adjusted for age, sex, parental history of asthma, parental history of atopy, in utero exposures to maternal smoking, ETS, dampness, incense burning, pet ownership at home and community.
†
Early-onset: asthma diagnosed ≦5 yr of age.
‡
Late-onset: asthma diagnosed >5 yr of age.
a
0: common allele and 1: minor allele, by the order of SNP1 (rs1800925): C/T; SNP2 (rs2066960): C/A; SNP3 (rs20541): C/T; SNP4 (rs848): G/T.