Table 8. Joint effects of carpet use and IL-13 haplotype h1011 on asthma phenotypes among children.
| h1011a | ||||||
| No | Yes | |||||
| Carpet use | OR | 95%CI | OR | 95%CI | P for interaction | |
| Asthma | No | 1 | 1.1 | (0.8,1.4) | 0.06 | |
| Yes | 0.6 | (0.3,1.1) | 1.7 | (0.8,3.6) | ||
| Wheeze | No | 1 | 1.2 | (0.9,1.5) | 0.01 | |
| Yes | 0.7 | (0.4,1.1) | 2.5 | (1.4,4.4) | ||
| Early-onset asthma† | No | 1 | 1.1 | (0.8,1.6) | 0.98 | |
| Yes | 0.5 | (0.2,1.1) | 0.5 | (0.1,2.2) | ||
| Late-onset asthma‡ | No | 1 | 1.0 | (0.6,1.7) | 0.02 | |
| Yes | 1.0 | (0.4,2.4) | 4.7 | (2.0,10.9) | ||
Models are adjusted for age, sex, parental history of asthma, parental history of atopy, in utero exposures to maternal smoking, ETS, dampness, incense burning, pet ownership at home and community.
†
Early-onset: asthma diagnosed ≦5 yr of age.
‡
Late-onset: asthma diagnosed >5 yr of age.
a
0: common allele and 1: minor allele, by the order of SNP1 (rs1800925): C/T; SNP2 (rs2066960): C/A; SNP3 (rs20541): C/T; SNP4 (rs848): G/T.