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. 2013 Jan 30;8(1):e54711. doi: 10.1371/journal.pone.0054711

Figure 2. The absence of α-synuclein does not modify PB-like inclusion biogenesis or morphology following 26S proteasomal depletion in mouse brain neurones.

Figure 2

(A and C) Representative inclusions (arrows) in neurones of the SNpc (Psmc1 fl/fl;TH Cre, A) and cortex (Psmc1 fl/fl;CaMKIIα-Cre, C) in the presence (Snca +/+) and absence (Snca −/−) of α-synuclein; from the top: hematoxylin and eosin staining, α-synuclein, p62, K48- and K63-specific polyubiquitin, and COX IV. 63×. (B) Absence of α-synuclein (Snca −/−) has no effect on the proportion of TH-positive neurones bearing eosinophilic inclusions in the 26S proteasome-depleted (Psmc1 fl/fl;TH Cre) SNpc. n = 3, no significant difference (ANOVA). Error bars indicate SEM.