Figure 1. Schedule for the administration of 5-fluorouracil (5-FU) and the effect of 5-FU on body weight and the diarrhea-score.

A) 5-FU (50 mg/kg, i.p.) or vehicle (saline, i.p.) was administered on Days 0–3. Twenty-four hours after the final administration of 5-FU, experiments were performed. B) Body weight decreased significantly under the repeated administration of 5-FU. C) Changes in the diarrhea-score during 5-FU-administration. The diarrhea-score significantly increased with 5-FU. Each point represents the mean ± S.E.M. of 6–9 mice. *p<0.05 and ***p<0.001 vs. vehicle (saline).