Figure 2. Changes in inflammatory cytokine gene expression in the intestines of mice treated with 5-FU.

Treatment with 5-FU increased the gene expressions of TNF-α (A), IL-1β(B), IL-6 (C), IFNγ (D), IL-17A (E) and IL-22 (F) different parts of the colon. Each column represents the mean ±S.E.M. of 4–6 independent experiments. *p<0.05, **p<0.01 and ***p<0.001 vs. vehicle (saline).