Figure 7. Effects of etanercept on the 5-FU-induced downregulation of aquaporin gene expression in the colons of mice.

The 5-FU-induced downregulation of AQPs 1 (A and E), 4 (B and F), 8 (C and G) and 11 (D and H) in the transverse (A–D) and distal (E–H) colons was not recovered by the administration of etanercept. Each column represents the mean ± S.E.M. of 4–6 independent experiments. **p<0.01 and ***p<0.001 vs. Saline+saline. ^#p<0.05, ^##p<0.01 and ^###p<0.001 vs. Saline +5-FU.