Figure 4. αB-Conotoxin VxXXIVA differentially blocks α9α10, α7, α3β4 and α4β2 nAChRs.

nAChR subtypes were expressed as described in Materials and Methods. “C” indicates control responses to ACh. Oocytes were then exposed to 10 µM peptide for 5 min, followed by application of ACh. The peptide blocked α9α10 but not α7, α3β4 or α4β2 nAChRs.