Table 3. IC50 and Hill slope values for block of rat nAChR subtypes by αB-Conotoxin VxXXIVA [1], [2].
nAChR subtype | IC50 | IC50 C.I. | Hill Slope | Hill Slope C.I. |
Rat α2β2 | 23.4 µM | 17.3–31.5 µM | 1.1 | 0.7–1.5 |
Rat α2β4 | >30 µM | – | – | – |
Rat α3β2 | >30 µM | – | – | – |
Rat α3β4 | >30 µM | – | – | – |
Rat α4β2 | >30 µM | – | – | – |
Rat α4β4 | >30 µM | – | – | – |
Rat α6/α3β2β3 | 12.2 µM | 10.0–14.9 µM | 1.2 | 0.9–1.7 |
Rat α6/α3β4 | 30.1 µM | 18.8–48.0 µM | 1.0 | 0.5–1.5 |
Rat α7 | >30 µM | – | – | – |
Rat α9α10 | 1.2 µM | 0.8–1.7 µM | 1.4 | 0.5–2.1 |
Mouse α1β1γδ | 6.6 µM | 5.1–8.5 µM | 1.2 | 0.8–1.6 |
C.I., 95% confidence interval.