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Effect of T140A in the absence of AcrA or AcrBa
| TolC protein | Zone of inhibition (mm) in presence of antibiotic
|
|||
|---|---|---|---|---|
| AcrA− AcrB+
|
AcrA+ AcrB−
|
|||
| Erythromycin (15 μg) | Novobiocin (30 μg) | Erythromycin (15 μg) | Novobiocin (30 μg) | |
| TolC+ | 16 | 18 | 16 | 19 |
| TolC− | 18 | 21 | 16 | 20.5 |
| TolCR367H | 25 | 21 | 25.5 | 20 |
| TolCR367H,T140A | 23 | 18.5 | 22 | 18.5 |
The diameter of the paper disks was 6.5 mm. Averages from three independent experiments are shown.
