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. 2013 Jan 30;8(1):e54774. doi: 10.1371/journal.pone.0054774

Figure 1. Arsenic trioxide (As2O3)-induced growth inhibition and apoptosis of gastric cancer FU97 cells.

Figure 1

(A) Cellular growth inhibition measured by MTT assay. Data are mean ± SD of 3 independent experiments. (B) Agarose gel analysis of DNA fragmentation in FU97 cells treated with As2O3 for 72 h.(C) Apoptotic nuclei stained with Hoechst 33258 show intense fluorescence corresponding to chromatin condensation and fragmentation.(D) Western blot analysis of caspase3 protein in total cell extracts of FU97 cells treated with the indicated concentration of As2O3 for 72 h. GAPDH expression served as loading control.