Table 1.
Composition of all liposomal suspensions used within this study and characterization concerning their size, polydispersity and zeta potential after coupling the polymer to the liposome (means ± SD; n ≥ 3).
| Sample description | Lipid composition a | Added polymer b | Size [nm] | Polydispersity index | Zeta potential [mV] |
|---|---|---|---|---|---|
| Uncoated liposomes | DPPC/DPPE-MCC | – | 201.3 ± 1.5 | 0.091 ± 0.023 | − 32.68 ± 1.99 |
| CS-TGA77-coated liposomes | DPPC/DPPE-MCC | CS-TGA, 77kD | 354.5 ± 3.4 | 0.213 ± 0.036 | 28.90 ± 1.45 |
| CS-TGA150-coated liposomes | DPPC/DPPE-MCC | CS-TGA, 150kD | 590.2 ± 18.9 | 0.629 ± 0.155 | 35.85 ± 3.19 |
| CS-TGA150-MNA-coated liposomes | DPPC/DPPE-MCC | CS-TGA-MNA, 150 kDa | 702.6 ± 138 | 0.738 ± 0.264 | 8.62 ± 1.36 |
a
The molar ratio of DPPC to DPPE-MCC was in all cases 3:0.3.
b
A polymer to lipid weight ratio of 1:1 was used for all formulations.