TABLE 1.
Vaccine | Route | Relative parasite burdena | Immunofluorescent antibody titer
|
||
---|---|---|---|---|---|
Sporozoiteb | Blood stageb | Liver stagec | |||
PY00835 | Gene gun | −0.1 | 2,560 | 20 | ND |
IM | 0.3 | Neg | Neg | ND | |
PY01316 | Gene gun | −1.3* | 2,560 | 20 | Neg |
IM | 0.5 | Neg | Neg | ND | |
PY01828 | Gene gun | 0.1 | 2,560 | 640 | Pos |
IM | 0.1 | Neg | Neg | ND | |
CSP | Gene gun | −0.1 | 2,560 | Neg | Neg |
IM | −2.7* | 2,560 | Neg | ND |
Parasite burden in liver is in comparison with that in challenged unvaccinated mice and is expressed as log10. *, parasite burden significantly different (P < 0.05) versus that in challenged unvaccinated mice.
Shown are the antibody titers from pooled antisera. Values are the last dilution at which florescence was detected. Neg, negative; Pos, positive; ND, not done.
Sera tested at a single dilution (1:80).