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. 2012 Oct 22;8:196. doi: 10.1186/1746-6148-8-196

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Copyright ©2012 Deng et al.; licensee BioMed Central Ltd.

This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.

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Transgenic goats over-expressing Capra hircus TLR2 monocytes and macrophages under Pam3CSK4 stimulation. Promotion of IL-6 and IL-10 expression in transgenic goats, ELISA testing of changes in inflammatory cytokines: (A) IFN-γ, (B) IL-6, and (C) IL-10 expression.(D, E) Prevention oxidative damage in transgenic goats, levels of NO and MDA expression. (F) Up-regulation of lysozyme secretion in transgenic goats by ELISA. Data are means ± SE. * Values within the same concentration of Pam3CSK4 (1 μg/mL) were found to differ significantly between different groups at different times (P<0.05). Tg = transgenic group, WT = wild-type group.