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. 2004 Mar;72(3):1530–1536. doi: 10.1128/IAI.72.3.1530-1536.2004

TABLE 2.

Populations of purified CD4+ T lymphocytes that traverse HUVEC are enriched for cells that secrete IFN-γ

Donor % of CD4+ T lymphocytes secreting IFN-γ
Initial population Migrated across unstimulated HUVECa Migrated across IL-1β-treated HUVECab Migrated across B. burgdorferi-treated HUVECa,b
B 30 62 53 62
E 26 51 38 49
F 12 39 29 34
a

All migrated populations showed significant enrichment for cells that secrete IFN-γ compared to the initial population (P < 0.05).

b

On average, 2.3 ± 0.8-fold more T lymphocytes traversed stimulated HUVEC than unstimulated endothelium in these experiments.