TABLE 2.
TB in rabbits 5 weeks after aerosol infection with M. tuberculosis H37Rv luciferase
| Parameter | Rabbit group
|
P | |
|---|---|---|---|
| Inbred | Outbred | ||
| No. of rabbits | 12 | 6 | |
| No. of tubercles (mean ± SE) | 98 ± 12 | 33 ± 13 | 0.007 |
| Avg diam of tubercles (mean ± SE) (mm) | 2.73 ± 0.13 | 1.43 ± 0.09 | 0.001 |
| Tuberculin reaction (mm3) | 289 ± 35 | 1,152 ± 348 | 0.009 |
| Mean no. of CFU ± SE (no. of rabbits) in: | |||
| Lymph nodea | 697 ± 192 (9 of 11) | 26 ± 20 (2 of 6) | 0.004 |
| Granulomab | 809 ± 210 (12 of 12) | 215 ± 115 (5 of 6) | 0.027 |
| Right upper lung lobe | 11,475 ± 9,448 (11) | 1,154 ± 986 (6) | 0.003 |
a
Bacillary CFU in both right and left hilar lymph nodes.
b
Bacillary CFU in typical granuloma from each rabbit.