TABLE 3.
Serotypes, disease associations, cdt alleles, and CDT titers of CDT+ STEC strains
| Strain/yr of isolation | Serotype | Disease associationa | cdt alleleb | CDT titer (CHO cells)d |
|---|---|---|---|---|
| 2996/96 | O73:H18 | HUS | cdt-Vc | 2-4 |
| 1745/97 | O91:H21 | D | cdt-V | 4 |
| 3332/99 | O91:H21 | HUS | cdt-V | 4 |
| 6605/00 | O91:H21 | D | cdt-V | 4 |
| 4292/01 | O91:H21 | D | cdt-V | 2-4 |
| 9101/01 | O91:H21 | D | cdt-V | 4 |
| 9108/01 | O91:H21 | D | cdt-V | 2-4 |
| 9282/01 | O91:H21 | D | cdt-Vc | 2-4 |
| 1269/02 | O91:H21 | D | cdt-V | 4-8 |
| 2596/02 | O91:H21 | HUS | cdt-V | 4 |
| 691/99 | O113:H21 | D | cdt-V | 16 |
| 6090/00 | O113:H21 | D | cdt-V | 32-64 |
| 2896/01 | O113:H21 | D | cdt-V | 64 |
| 5249/01 | O113:H21 | D | cdt-Vc | 16-32 |
| 5107/00 | O153:H18 | D | cdt-III | 4-8 |
| 7272/02 | O153:H18 | D | cdt-III | 4-8 |
| 9063/02 | O153:H18 | D | cdt-IIIc | 8 |
a
HUS, hemolytic uremic syndrome (defined as microangiopathic hemolytic anemia, thrombocytopenia, and renal insufficiency [7]); D, watery diarrhea.
b
As detected by PCR.
c
Confirmed by sequence analysis.
d
The reciprocal of the highest dilution of a culture filtrate that distended 50% of CHO cells after 5 days of incubation. CDT titers or titer ranges obtained for each strain in three independent experiments are shown; no (where only one titer value is given) or only nonsignificant (1 dilution) titer differences were observed at the repeat testings.