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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Mol Med (Berl). 2013 Jan 8;91(2):157–164. doi: 10.1007/s00109-012-0990-0

Figure 2. Model of adenosine-mediated epithelial restitution following PMN migration.

Figure 2

Adenosine-mediated signaling increases levels of cAMP in epithelial cells and results in the activation of protein kinase A (PKA), and subsequent phosphorylation of VASP. In this model, phospho-VASP interactions with actin and tight junction proteins contribute to diminishing paracellular permeability through relaxation of actin cytoskeletal tension. Such a mechanism contributes to the resealing of epithelial monolayers following PMN transmigration.