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. Author manuscript; available in PMC: 2014 Feb 1.
Published in final edited form as: J Mol Med (Berl). 2013 Jan 8;91(2):157–164. doi: 10.1007/s00109-012-0990-0

Figure 3. Molecular mechanism of anti-inflammation by adenosine.

Figure 3

The canonical NFκB pathway is activated through the phosphorylation of IκB. This phosphorylation allows for its recognition by the neddylated Skp-Cullin-F-Box (SCF) complex, polyubiquitination and subsequent proteasomal degradation. Neddylation of Cul-1 is achieved through a multienzyme process, conjugating a NEDD8 moiety to the target protein (see text). Adenosine receptor activation, as well as the neddylation inhibitor MLN4924, inhibit Cullin neddylation or promote deneddylation of Cullin-proteins, thereby inhibiting the overall function of the SCF complex.