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. Author manuscript; available in PMC: 2013 Jan 31.
Published in final edited form as: Adv Biol Regul. 2011 Sep 12;52(1):66–76. doi: 10.1016/j.advenzreg.2011.09.012

fig 3. PIKE −/− mice are more susceptible to KA-induced seizure.

fig 3

A. PIKE depletion increases seizure scores. Adult (2 to 3-month-old) wild-type (□) and PIKE −/− (■) mice were injected intraperitoneally with KA (20 mg/kg). Induced seizure after KA injection was then scored (*: P<>0.01, two-way ANOVA, n=6).

B. Representative EEG recording before and after KA (15 mg/kg) injection in wild-type animals.

C. KA-provoked more spike discharge in PIKE −/− mice. Number of spike-wave discharges that were higher than the basal levels during the EEG examination in the wild-type and PIKE −/− mice after 15 mg/kg KA injection was quantified (*: P<0.05, Student's t-test, n=4).