Table 2.

Summary of six primary and two secondary independent loci (P < 5.0×10⁻⁸) obtained for PR in 13,415 African-American participants from ten cohort studies.

SNP	Gene	Chr	Position (Build 36)	Allelesa	Effect allele Frequency	Study-specific direction of βb	β (se)	p	phet
Primary signalsc
rs3891585	MEIS1	2	66,610,480	A/G	0.43	+−++−+++++	2.13 (0.31)	1.42 × 10−11	0.11
rs267567	ITGA9	3	37,549,028	A/G	0.18	+++−++++++	2.73 (0.41)	4.14 × 10−11	0.54
rs3922844	SCN5A	3	38,599,257	T/C	0.58	−−−−−−−−−−	−4.54 (0.33)	5.26 × 10−43	0.58
rs11732231	ARHGAP2 4	4	86,902,584	C/G	0.23	++++++++++	2.28 (0.39)	2.96 × 10−9	0.30
rs11773845	CAV1	7	115,978,537	A/C	0.36	−−−−−−−−−−	−2.29 (0.33)	4.45 × 10−12	0.53
rs1895585	TBX5	12	113,286,521	A/G	0.30	++−+++++++	3.19 (0.35)	1.36 × 10−19	0.42
Secondary signalsd
rs6763048	SCN5A	3	38,656,398	A/G	0.73	++++++++++	2.62 (0.38)	3.75 × 10−12	0.74
rs6801957	SCN10A	3	38,742,319	T/C	0.27	++++	3.36 (0.58)	9.11 × 10−9	0.15

^aCoded allele listed first.

^bStudy-specific direction of β estimates are listed in alphabetical order by study. The + and − symbols represent an increase and decrease, respectively, in the PR interval per copy of the minor allele.

^cDefined as locus-specific SNP with the lowest P-value.

^dDefined as significant SNPs after conditional analysis that adjusted for locus-specific primary signal. The conditional analysis for rs6801957 was performed in four cohorts (CHS, HABC, HANDLS and WHI) adjusting for successively less significant SNPs until no genome-wide significant SNPs remained.

Chr, chromosome; se, standard error; p, meta-analysis p-value; p_het, Cochran’s Q heterogeneity p-value.