Table 2.
Summary of six primary and two secondary independent loci (P < 5.0×10−8) obtained for PR in 13,415 African-American participants from ten cohort studies.
| SNP | Gene | Chr | Position (Build 36) |
Allelesa | Effect allele Frequency |
Study-specific direction of βb |
β (se) | p | phet |
|---|---|---|---|---|---|---|---|---|---|
| Primary signalsc | |||||||||
| rs3891585 | MEIS1 | 2 | 66,610,480 | A/G | 0.43 | +−++−+++++ | 2.13 (0.31) | 1.42 × 10−11 | 0.11 |
| rs267567 | ITGA9 | 3 | 37,549,028 | A/G | 0.18 | +++−++++++ | 2.73 (0.41) | 4.14 × 10−11 | 0.54 |
| rs3922844 | SCN5A | 3 | 38,599,257 | T/C | 0.58 | −−−−−−−−−− | −4.54 (0.33) | 5.26 × 10−43 | 0.58 |
| rs11732231 |
ARHGAP2 4 |
4 | 86,902,584 | C/G | 0.23 | ++++++++++ | 2.28 (0.39) | 2.96 × 10−9 | 0.30 |
| rs11773845 | CAV1 | 7 | 115,978,537 | A/C | 0.36 | −−−−−−−−−− | −2.29 (0.33) | 4.45 × 10−12 | 0.53 |
| rs1895585 | TBX5 | 12 | 113,286,521 | A/G | 0.30 | ++−+++++++ | 3.19 (0.35) | 1.36 × 10−19 | 0.42 |
| Secondary signalsd | |||||||||
| rs6763048 | SCN5A | 3 | 38,656,398 | A/G | 0.73 | ++++++++++ | 2.62 (0.38) | 3.75 × 10−12 | 0.74 |
| rs6801957 | SCN10A | 3 | 38,742,319 | T/C | 0.27 | ++++ | 3.36 (0.58) | 9.11 × 10−9 | 0.15 |
Coded allele listed first.
Study-specific direction of β estimates are listed in alphabetical order by study. The + and − symbols represent an increase and decrease, respectively, in the PR interval per copy of the minor allele.
Defined as locus-specific SNP with the lowest P-value.
Defined as significant SNPs after conditional analysis that adjusted for locus-specific primary signal. The conditional analysis for rs6801957 was performed in four cohorts (CHS, HABC, HANDLS and WHI) adjusting for successively less significant SNPs until no genome-wide significant SNPs remained.
Chr, chromosome; se, standard error; p, meta-analysis p-value; phet, Cochran’s Q heterogeneity p-value.