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. Author manuscript; available in PMC: 2013 Dec 1.
Published in final edited form as: Circ Cardiovasc Genet. 2012 Nov 8;5(6):639–646. doi: 10.1161/CIRCGENETICS.112.963991

Table 3.

Associations between PR and three previously reported PR loci10 that were not genome-wide significant in a meta-analysis of 13,415 African-American participants from ten cohort studiesi.

SNP Gene Chr Position
(Build 36)		 Allelesa Effect Allele
Frequency		 Study-specific
direction of βb 		β (se) p phet
rs251253 NKX2–5 5 172,412,942 T/C 0.36 −++++++−++ 0.77 (0.33) 1.84 × 10−2 0.53
rs4944092 WNT11 11 75,587,267 A/G 0.57 ++−+++++−+ 0.41 (0.32) 2.05 × 10−1 0.18
rs11047543 SOX5 12 24,679,606 A/G 0.03 −+???−−−+? −2.49 (1.25) 4.57 × 10−2 0.12
a

Coded allele listed first.

b

Study-specific direction of β estimates are listed in alphabetical order of the studies. The + and − symbols represent an increase and decrease, respectively, in the PR interval per copy of the minor allele. A “?” denotes studies that did not contribute to the SNP meta-analysis.

Chr, chromosome; se, standard error; p, meta-analysis p-value; phet, Cochran’s Q heterogeneity p-value.