TABLE 2.
Prevalence of antibodies to rMSP-119, their ability to compete with MAbs, and association with age and subsequent parasitemia for Ugandan children m
| Parameter | n | rMSP119 | No. (%) of the following antibodies that gave an OD of >0.263 at the indicated dilution:
|
|||||||||||||||||
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 12.8
|
12.10
|
1E1
|
7.5
|
8A12a
|
2F10a
|
|||||||||||||||
| 1:50 | 1:250 | Combined | 1:50 | 1:250 | Combined | 1:50 | 1:250 | Combined | 1:50 | 1:250 | Combined | 1:50 | 1:250 | Combined | 1:50 | 1:250 | Combined | |||
| Total | 156 | 94 (60) | 41 (26) | 54 (35) | 95 (61) | 27 (17) | 58 (37) | 85 (54) | 36 (23) | 55 (35) | 91 (58) | 34 (22) | 47 (30) | 81 (52) | 30 (20) | 48 (32) | 78 (52) | 24 (16) | 43 (28) | 67 (44) |
| Age group (yr) | ||||||||||||||||||||
| 7-9 | 27 | 16 (59) | 11 (41) | 6 (22) | 6 (22) | 7 (26) | 5 (19) | 10 (37) | 7 (26) | 8 (30) | 7 (27) | 7 (27) | 3 (12) | 7 (27) | ||||||
| 10-12 | 85 | 49 (58) | 16 (19) | 32 (38) | 10 (12) | 34 (40) | 18 (21) | 30 (35) | 17 (20) | 23 (27) | 13 (15) | 26 (31) | 13 (15) | 22 (26) | ||||||
| 13-16 | 44 | 29 (66) | 14 (32) | 16 (36) | 11 (25) | 17 (39) | 13 (30) | 15 (34) | 10 (23) | 16 (36) | 10 (24) | 15 (37) | 8 (20) | 14 (34) | ||||||
| χ2 (P)b | 0.89 (0.34) | 0.43 (0.51) | 1.92 (0.17) | 0.57 (0.45) | 0.27 (0.60) | 0.65 (0.42) | 1.77 (0.18) | |||||||||||||
| Maximum parasitemiac | ||||||||||||||||||||
| <1,000 | 58 | 40 (69) | 17 (29) | 21 (36) | 8 (14) | 28 (28) | 10 (17) | 27 (47) | 13 (22) | 22 (38) | 10 (17) | 25 (44) | 12 (21) | 22 (39) | ||||||
| 1,000-5,000 | 70 | 38 (54) | 16 (23) | 25 (36) | 9 (13) | 24 (34) | 17 (24) | 22 (31) | 13 (19) | 19 (27) | 13 (19) | 19 (28) | 5 (7) | 18 (26) | ||||||
| >5,000 | 28 | 16 (57) | 8 (29) | 8 (29) | 10 (36) | 6 (21) | 9 (32) | 6 (21) | 8 (29) | 6 (21) | 7 (28) | 4 (16) | 7 (28) | 3 (12) | ||||||
| χ2 (P)d | 1.81 (0.18) | 0.73 (0.39) | 0.67 (0.42) | 1.04 (0.31) | 1.47 (0.23) | 2.97 (0.08) | 5.17 (0.023) | |||||||||||||
| χ2 (P)e | 0.38 (0.54) | 6.28 (0.012) | 5.93 (0.015) | 2.87 (0.09) | 7.19 (0.007) | 6.38 (0.012) | ||||||||||||||
a
Data for 8A12 and 2F10 were obtained only for 151 children.
b
Trend across age groups (1 df) for a comparison of sera that competed at either dilution (1:50 or 1:250) with sera that did not compete.
c
Parasites per microliter over 14 follow-up visits.
d
Trend across parasitemia groups (1 df) for a comparison of sera that competed at either dilution (1:50 or 1:250) with sera that did not compete.
e
Trend across parasitemia groups (1 df) for a comparison of sera that competed at a dilution of 1:250 with sera that competed at 1:50 or did not compete.