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Safety of MVA-plague vaccines in severe combined immune deficient (SCID) mice.
SCID mice were infected intraperitoneally with MVA/plague constructs (dose: 1 X 108 pfu), wild type MVA (MVAwt, dose: 1 X 108 pfu), or vaccinia virus Wyeth strain (dose: 1 X 106 pfu) and were weighed weekly for 12 weeks. Mice were euthanized when showing body conditioning score less than two (BCS < 2) or died naturally.
