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. Author manuscript; available in PMC: 2013 Jan 31.
Published in final edited form as: Mol Ther. 2008 Jun 17;16(8):1409–1416. doi: 10.1038/mt.2008.116

Figure 3. Murine IL-4 expression in pancreatic islet β-cells of female NOD mice reduced the onset of hyperglycemia.

Figure 3

Four week old female NOD mice received dsAAV8 expressing either vehicle (n=35), GFP (n=24), mIL-4 (n=29), mIL-10 (n=20), mIκB (n=13) super-repressor and 8 week old NOD mice received ds-AAV-mIL-4 (n=10). The onset of diabetes was monitored as described in methods. A significant number of 4 week old (a) and eight week old (b) mice treated with dsAAV8-mIP-IL-4 were normal as compared to eGFP and vehicle control recipient mice. Whereas, there was no difference in the incidence of diabetes in mIL-10 and mIκB treated mice as compared to controls. A p value of less than 0.05 by long rank test analysis was used to indicate statistically significant percentage normo-glycemic (* p<0.001, # non-significant).