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. Author manuscript; available in PMC: 2013 Jan 31.
Published in final edited form as: Mol Ther. 2008 Jun 17;16(8):1409–1416. doi: 10.1038/mt.2008.116

Figure 4. Histochemical analysis of infiltrating leukocytes in twenty week normo-glycemic mice.

Figure 4

Photomicrographs of H&E for infiltrating leukocytes in female 8 and 21 week normoglycemic female NOD mice showed mild to severe mononuclear cell infiltration in and around islets of saline and GFP treated mice (Figs. 4a–b; e–f), whereas the dsAAV8-mIP-IL-4 treated mice showed limited peri-islet mononuclear cell infiltration in significantly fewer numbers of islets (Figs. 4c, f). Figure 4g shows the insulitis score determined as mentioned in methods. Magnification 100X.