Figure 5. Electrical stimulation inducing nuclear abnormality in cardiomyocytes derived from LMNA^R225X/WT &LMNA^{Frameshift/WT} iPSCs.

(A) Representative immunofluorescence staining of cardiomyocytes derived from LMNA^WT/WT iPSCs, LMNA^R225X/WT iPSCs, LMNA^{Frameshift/WT} iPSCs, LMNA^WT/WT iPSCs treated with mock shRNA, and LMNA^WT/WT iPSCs treated with shLMNA at baseline and after electrical stimulation. (B) The percentage of cardiomyocytes showed nuclear blebs.