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. 2012 Nov 30;4(11):768–789. doi: 10.18632/aging.100499

Table 6. Features common to aging and individual stress factors.

  1. GO enrichment terms for genes up-regulated in aging and in hyperoxia

    GO:0009408 response to heat(16) 2.64E-11
    GO:0009266 response to temperature stimulus(17) 1.15E-10
    GO:0006950 response to stress(34) 9.95E-08
    GO:0035079 polytene chromosome puffing(5) 3.88E-05
    GO:0035080 heat shock-mediated polytene chromosome puffing(5) 3.88E-05
    GO:0009628 response to abiotic stimulus(17) 8.38E-05
    GO:0044271 cellular nitrogen compound biosynthetic process(14) 0.00202
    GO:0034605 cellular response to heat(6) 0.002657
    GO:0019731 antibacterial humoral response(7) 0.009046
    GO:0009156 ribonucleoside monophosphate biosynthetic process(5) 0.032356
    GO:0009161 ribonucleoside monophosphate metabolic process(5) 0.032356
    GO:0006564 L-serine biosynthetic process(3) 0.04487

  2. GO enrichment terms for genes down-regulated in aging and in hyperoxia

    GO:0006508 Proteolysis(56) 6.01E-18
    GO:0045297 post-mating behavior(7) 9.33E-04
    GO:0008152 metabolic process(131) 0.00614

  3. GO enrichment terms for genes up-reguated in aging and in hydrogen peroxide

    GO:0009408 response to heat(11) 4.75E-06
    GO:0035079 polytene chromosome puffing(5) 1.44E-05
    GO:0035080 heat shock-mediated polytene chromosome puffing(6) 1.44E-05
    GO:0006950 response to stress(27) 2.86E-05
    GO:0009266 response to temperature stimulus(11) 7.87E-05
    GO:0034605 cellular response to heat(6) 8.32E-04
    GO:0044271 cellular nitrogen compound biosynthetic process(13) 0.001277
    GO:0009069 serine family amino acid metabolic process(5) 0.005345
    GO:0044281 small molecule metabolic process(24) 0.005367
    GO:0006564 L-serine biosynthetic process(3) 0.024923
    GO:0051707 response to other organism(11) 0.032029
    GO:0009607 response to biotic stimulus(11) 0.035404

  4. GO enrichment terms for genes down-reguated in aging and in hydrogen peroxide

    GO:0006091 generation of precursor metabolites and energy(12) 0.001493
    GO:0022900 electron transport chain(9) 0.001518
    GO:0055114 oxidation-reduction process(22) 0.002986
    GO:0045333 cellular respiration(10) 0.003694
    GO:0015980 energy derivation by oxidation of organic compounds(10) 0.008153
    GO:0022904 respiratory electron transport chain(8) 0.010626
    GO:0042775 mitochondrial ATP synthesis coupled electron transport(7) 0.043253

  5. GO enrichment terms for genes up-regulated in aging and in heat stress

    GO:0009408 response to heat(18) 1.04E-21
    GO:0009266 response to temperature stimulus(18) 1.68E-19
    GO:0009628 response to abiotic stimulus(18) 8.84E-13
    GO:0006950 response to stress(22) 1.70E-08
    GO:0006457 protein folding(11) 1.90E-07
    GO:0035079 polytene chromosome puffing(5) 4.29E-07
    GO:0035080 heat shock-mediated polytene chromosome puffing(5) 4.29E-07
    GO:0034605 cellular response to heat(6) 1.27E-05
    GO:0001666 response to hypoxia(6) 0.001193
    GO:0070482 response to oxygen levels(6) 0.002157
    GO:0042221 response to chemical stimulus(14) 0.031137

  6. GO enrichment terms for genes down-regulated in aging and in heat stress

    GO:0006508 Proteolysis(25) 1.75E-07

  7. GO enrichment terms for genes up-regulated in aging and Ionizing radiation

    GO:0006950 response to stress(33) 2.17E-06
    GO:0009408 response to heat(12) 5.07E-06
    GO:0035079 polytene chromosome puffing(5) 5.04E-05
    GO:0035080 heat shock-mediated polytene chromosome puffing(5) 5.04E-05
    GO:0009266 response to temperature stimulus(12) 1.05E-04
    GO:0034605 cellular response to heat(6) 0.003611
    GO:0009069 serine family amino acid metabolic process(5) 0.018171
    GO:0044271 cellular nitrogen compound biosynthetic process(13) 0.022327
    GO:0033554 cellular response to stress(18) 0.024714

  8. GO enrichment terms for genes down-regulated in aging and Ionizing radiation

    GO:0006091 generation of precursor metabolites and energy(17) 2.30E-07
    GO:0045333 cellular respiration(14) 1.95E-06
    GO:0015980 energy derivation by oxidation of organic compounds(14) 6.16E-06
    GO:0022900 electron transport chain(11) 4.47E-05
    GO:0055114 oxidation-reduction process(26) 2.65E-04
    GO:0006119 oxidative phosphorylation(10) 2.91E-04
    GO:0022904 respiratory electron transport chain(10) 2.91E-04
    GO:0042775 mitochondrial ATP synthesis coupled electron transport(9) 9.52E-04
    GO:0042773 ATP synthesis coupled electron transport(9) 0.00164