Table 2.

Genes involved in sporadic and familial AD, the homologous genes in zebrafish and the percentage of protein sequence homology.

Human Gene	Zebrafish gene	Protein homology	Reference
APP	appa	70%	[111]
	appb	70%
PSEN1	psen1	74%	[118]
PSEN2	psen2	74%	[119]
Pen2	Pen2	74%	[129]
Aph1A&B	Aph1	62%	[129]
Nicastrin	Nicastrin	56%	[128]
TAU	mapta/maptb	Unidentified	[135]
APOE	APOE	28%	[143]