Table 3.

Zebrafish transgenic/knockdown models for AD (CNS: Central Nervous System. MO: morpholino).

Human Gene	Zebrafish gene	Protein homology	Reference
APP	appb promoter- GFP	appb expression in larvae and adults	[113]
	appa and appb MO	Reduced body weight & defective movements	[114]
PSEN1	psen1 MO	Somite defects & defective brain development	[120,121]
PSEN2	psen2 MO	Altered gene expression & CNS defects	[123,124]
TAU	Transient overexpression of 4R-Tau-GFP	TAU phosphorylation & tangle-like structures	[137]
	Human 4R/0N tau	TAU accumulation resembling tangles	[136]
	Human TAU-P301L	TAU hyperphosphorylation, tangles & neuronal death	[138]