Skip to main content
. 2012 May 16;1(1):107–118.

Figure 1.

Figure 1

Evolutionary sequence conservation of novel PSEN2 mutation p.Phe183Ser and homology with PSEN1. ClustalW alignment for the part of PSEN2 with the novel p.F183S mutation. Shown are human PSEN2 (NP_036618.2), chimpanzee PSEN2 (XP_001142009.2), cow PSEN2 (NP_776865.2), mouse PSEN2 (NP_001122077.1), rat PSEN2 (NP_112349.2), chicken (NP_989633.1) and human PSEN1 (NP_000012.1). Amino acid positions of PSEN2 codons are indicated above the alignment. Position 183 in PSEN2 corresponds with position 177 in PSEN1 previously reported to carry the corresponding p.Phe177Ser pathogenic mutation (ref).