Figure 1.

Schematic Overview of the Experimental Design. Animals were first subjected to burn or sham burn treatments, and then 48 hours later, were subjected to cecal ligation and puncture. Sacrifice occurred at 2, 4, 8, 12, 16, 20, 24, 48, 120, and 192 hours post CLP. Microarray data from the liver was preprocessed using dChip software, and then compared using SAM (Statistical Analysis of Microarrays) to determine genes with significantly altered expression. This subset of genes was then processed using Ingenuity Pathway Analysis enrichment software in order to characterize the biological differences between the two injury models.