Figure 4.
Protein-DNA contacts in the base lesion pocket. (a) Diagram of interactions involved in hypoxanthine recognition, shown in both side-view and front-view. Hydrogen bonds and steric interactions shown with dashed lines; the van der Waals volumes of selected residues involved in hypoxanthine contacts represented by dotted surfaces. (b) Tautomeric forms of hypoxanthine and detailed hydrogen bonding network. (c) Tautomeric forms of xanthine and detailed hydrogen bonding network. (d) Model of uracil binding to EndoV.