Table 1.
Brain-related genes with significant main effects of ethanol exposure at G12
| Transcript ID | Gene | Symbol | EtOH | Corrected | Sex | Area | Sex × EtOH |
EtOH × Social |
Functions |
|---|---|---|---|---|---|---|---|---|---|
| 10851991 | Activity-dependent neuroprotector homeobox |
Adnp | 0.00135 | 0.04708 | 0.2823 | 0.7467 | 0.1743 | 0.0115 | Potential transcription factor. May mediate some neuroprotective peptide VIP- associated effects. |
| 10787435 | Arrestin domain containing 2 |
Arrdc2 | 0.00008 | 0.03408 | 0.0232 | 0.0450 | 0.2834 | 0.0056 | Possibly involved in regulating signal transduction. |
| 10727453 | Calcium binding protein 4 |
Cabp4 | 0.00134 | 0.04708 | 0.0562 | 0.2995 | 0.1096 | 0.0133 | Involved in normal synaptic function through regulation of Ca(2+) influx and neurotransmitter release. May suppress calcium-dependent inactivation and shift the activation range to more hyperpolarized voltages. |
| 10788699 | Cholinergic receptor, nicotinic, alpha 6 |
Chrna6 | 0.00148 | 0.04906 | 0.9970 | 0.1925 | 0.3796 | 0.0058 | Receptor for acetylcholine, changes conformation, leading to opening of an ion-conducting channel. |
| 10757698 | Frizzled homolog 9 (Drosophila) |
Fzd9 | 0.00034 | 0.04342 | 0.0093 | 0.5258 | 0.1679 | 0.0071 | Receptor for Wnt proteins. Coupled to the beta-catenin canonical signaling pathway, which leads to the activation of disheveled proteins, inhibition of GSK- 3 kinase, nuclear accumulation of beta-catenin and activation of Wnt target genes. |
| 10800726 | Mitogen activated protein kinase kinase kinase 2 |
Map3k2 | 0.00126 | 0.04708 | 0.0123 | 0.2400 | 0.3636 | 0.0736 | Component of a protein kinase signal transduction cascade. Regulates the Jnk and Erk5 pathways by phosphorylating and activating Map2k5 and Map2k7. |
| 10899890 | RAB5B, member RAS oncogene family |
Rab5b | 0.00135 | 0.04708 | 0.9269 | 0.2614 | 0.5690 | 0.3652 | Protein transport. Probably involved in vesicular traffic. |
| 10710848 | Rabaptin, RAB GTPase binding effector protein 2 |
Rabep2 | 0.00085 | 0.04708 | 0.1116 | 0.0308 | 0.3933 | 0.0077 | Plays a role in membrane trafficking and in homotypic early endosome fusion. |
| 10732565 | Regulator of G- protein signaling 11 |
Rgs11 | 0.00016 | 0.03547 | 0.0181 | 0.1182 | 0.6978 | 0.0021 | Inhibits signal transduction by increasing the GTPase activity of G protein alpha subunits thereby driving them into their inactive GDP-bound form |
| 10904714 | Scribbled homolog (Drosophila) |
Scrib | 0.00046 | 0.04342 | 0.1668 | 0.0383 | 0.4145 | 0.0789 | Scaffold protein involved in different aspects of polarized cells differentiation regulating epithelial and neuronal morphogenesis. May play a role in exocytosis and in the targeting of synaptic vesicles. |
Note: p values from the 3 way ANOVA are shown for each effect or interaction indicated. Only the EtOH effect was corrected for multiple testing (using an FDR step-up procedure). Note that none of the nominally-significant effects or interactions of the other factors survived FDR correction, but are listed for comparison purposes.