Fig. 6.

Puffs are terminated by IP₃R inhibition not local ER depletion. (A) Distribution of time to termination of puffs for f = 2.5, 5, and 10 (solid, dotted, and dashed line respectively). The inset is an expanded view from 600 ms to 1000 ms. (B) Termination time distribution for $C_{\mathit{ER}}^{\mathit{rest}}=700\mu \mathrm{M}$, 900 μM, and 1300 μM (solid, dotted, and dashed line respectively). (C) Local ER Ca²⁺ concentration for simulations in (B). Different line patterns correspond to the same $C_{\mathit{ER}}^{\mathit{rest}}$ values as in (B). The inset is an expanded view from 0 to 100 μM.