Figure 2.

Pedigree structures of the families with ventricular septal defect. Families are designated as family 1, family 2, family 3, and family 4. Family members are identified by generations and numbers. Squares indicate male family members; circles, female members; closed symbols, affected members; open symbols, unaffected members; arrow, proband; “+”, carriers of the heterozygous mutations; and “−”, non-carriers.