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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Future Med Chem. 2012 Jun;4(9):1093–1111. doi: 10.4155/fmc.12.58

Figure 18. Pathway for interstrand crosslink repair.

Figure 18

(A) The interstrand crosslink represents a block to polymerization; (B) one end of the crosslink is excised to yield a double strand break terminus, a gap and a lesion connected to the excised DNA; (C) the remaining unhooked monofunctional lesion is bypassed by translesion synthesis polymerase; (D) the remaining unhooked lesion is excised by nucleotide excision repair proteins; (E) polymerase fills in the gap in the DNA (F) homologous recombination is used to provide a template for DNA synthesis; (G) after resolution of the Holiday junction the DNA is fully repaired.