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. Author manuscript; available in PMC: 2013 Apr 1.
Published in final edited form as: Future Med Chem. 2012 Jun;4(9):1093–1111. doi: 10.4155/fmc.12.58

Figure 8. Human APE-1 protein.

Figure 8

(A) The amino acids that flank the enzymatic site of APE-1 are shown along with the DNA (orange) and the abasic site (green) adapted from PDB entry 1DEW [76]. (B) The proposed binding of E3330 (purple; see Figure 9 for structure) to APE-1 based on NMR studies (red and yellow represent amino acid residues whose chemical shifts change by >0.01 and >0.02 ppm, respectively, when E3330 is present) [84].