Relationship between MDZ and ALF clearances after IV administration. Each data point is an individual subject session. The correlation was significant (Pearson r=0.86, p<0.05). Similar significant correlations were found between MDZ and ALF for CL/F (r=0.72), hepatic extraction (EH, r=0.86), bioavailability (Foral, r=0.87), and intestinal extraction (EG, 0.68).